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CROSS-KINGDOM CELLULAR EQUILIBRIUM

Nature-Grounded Systemic Resilience

A bio-fermented botanical platform supporting proteostatic balance across humans, canines, forests, pollinators, and the mycelia that connect them all.

Explore the Kingdoms Secure Allocation
Interactive Systemic Visualization

Three Kingdoms of Proteostasis

One unified bio-fermented molecule protecting cellular resilience across Animalia, Plantae, and Funga.

Dynamic Molecular Chaperone Homology Engine
ANIMALIA PLANTAE FUNGA HSP70 CORE Smilax glabra Animalia • ESTABLISHED
Interactive Proteostasis Stress Simulator
Homeostatic Baseline
HSP70 Reserves: 1.0x (Normative)
Baseline Thermal 105°F Agrochemical Severe Duress
Animalia ESTABLISHED

Human Proteostasis

Dual Chemotype: Smilax glabra
Primary Actives: Astilbin (5.2% HPLC), Sarsasapogenin, Dihydroflavonols

Overview & Application

Supports whole-body protein folding equilibrium, endoplasmic reticulum (ER) stress resilience, and mucosal epithelial integrity under metabolic and environmental duress.

Molecular Pathway & Receptor Gating

Astilbin selectively modulates Store-Operated Calcium Entry (SOCE) at STIM1/Orai1 channels, preventing sustained intracellular Ca2+ overload and suppressing RAGE-ERK1/2-NF-kB inflammatory cascades while upregulating chaperone GRP78/BiP reserves.

Verified Scientific Evidence

  • Shin et al. (2015) — PLOS ONE, 10(12), e0145876
    Astilbin SOCE inhibition & ER folding
  • Vasquez et al. (2024) — PMC11936870
    Phytochemical proteostasis network modulation
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ESTABLISHED Direct peer-reviewed evidence
SUPPORTED Mechanism proven, application in testing
HYPOTHESIZED Plausible mechanism, translational model
Legacy & Philosophy

Indigenous Roots & Seventh Generation Stewardship

Guided by Creek heritage and a Seventh Generation philosophy, STIM.bio is built on the understanding that every decision we make must protect and serve the land and the people seven generations into the future.

Our journey began as a deep, five-year return to the soil, seeking natural, whole-plant balance for our family outside the boundaries of isolated synthetic chemical compounds. We honor the plant's full architecture so that it can honor yours.

Read Our Journey
A cross-section of healthy biological soil showing root networks intertwining with glowing mycorrhizal mycelium
Botanical Precision

Dual-Species Targeted Chemistry

We do not believe in one-size-fits-all extracts. STIM.bio deploys two distinct species of Smilax, each selected for its specific natural phytochemical profile.

STIM.bio Core Platform

Smilax glabra (Astilbin Rich)

Specialized for human cellular proteostasis, companion canine metabolic and gut mobility support (hypothesized), and forest root-zone mycorrhizal development.

  • Rich in dihydroflavonol glycoside Astilbin (5%+ HPLC)
  • Inhibits store-operated calcium overload (SOCE) at STIM1/Orai1
  • Protects mucosal epithelial barriers and tight junctions
STIM.buzz Standalone Platform

Smilax china (Laxogenin & Sapogenins)

Specialized for apiary thermal armor, flight muscle protection, and agrochemical neonicotinoid detoxification co-factors.

  • High concentration of Laxogenin brassinosteroid analogues
  • Bio-fermented spirostanol and furostanol aglycones
  • Induces worker bee thoracic HSP70 & CYP9Q detox enzymes

Secure Your Batch Allocation

Phase 1 whole-plant Smilax allocations are extremely limited due to our slow, artisanal bio-fermentation cycles. Entering your email reserves your batch and instantly creates your free account to unlock full molecular science dossiers and verified citations.